Uncommon Goods is one of my favorite destinations for online shopping. The company features homemade crafts and goods almost exclusively, and has a commitment to being an environmentally-conscious company. Perhaps best of all, they make sure that the wares that they hock are affordable to their consumers, but allow for enough money for the artisans to be satisfied.
I like Uncommon Goods particularly because the selection isn't overwhelming, and the items for purchase are smartly divided on the website. For example, during the holiday season, the website is divided into gifts for men, women, children, etc..., as well as by price and the type of product available. All of the gifts seem just a bit quirkier and individualized, like you handpicked a gift for a friend or relative, rather than just grabbed an unspecific gift.
Here are some of cool gift ideas available from Uncommon Goods: